In Vitro Research
MicroElectrode Array Stretching Stimulating und Recording Equipment(MEASSuRE)
Cells in the body are constantly subject to mechanical forces, with yet poorly understood effects on cell division, gene expression, cell migration, morpho-genesis, ion channel gating, and others. In a physiological stretch, the cells are stretched within their healthy limits. In a pathological stretch, the cells are stretched beyond the healthy limits and normal cell function is disrupted, causing a trauma.
It is currently difficult to investigate reproducibly and reliably the effects of physiological and pathological mechanical stretch on the electrophysiology of biological tissue, both in vitro and in vivo, because current electrodes are hard and stiff, thus break or damage the tissue upon stretching. Moreover, existing commercial technologies only allow to either stretch cells mechanically or to stimulate them electrically, but not both. MEASSuRE solves this problem.
MEASSuRE reproduces the mechanical and electrical in vivo environment in a controlled invironment in vitro by allowing the application of a controlled stretch (strain, strain rate) to a cell or tissue culture while simultaneously stimulating electrophysiolgical activity to assess the health of the cells. This capability is enabled by incorporating BMSEED’s proprietary elastically stretchable microelectrodes.
MEASSuRE addresses the in vitromarkets for mechanical stimulation, electrical stimulation/ recording, and optical imaging. BMSEED will also offer entry-level systems for those customers who only require mechanical stimulation or electrical stimulation/ recording. The entry-level configurations can be upgraded to the complete MEASSuRE configuration.