pCLAMP™ Software Suite

Patch Clamp – Software

Category:

Overview

The Axon™ pCLAMP™ Software Suite is the most widely-used patch-clamp electrophysiology data acquisition and analysis program for control and recording of voltage-clamp, current-clamp, and patch-clamp experiments.

The software suite consists of:

  • Axon Clampex 11 Software for data acquisition
  • Axon AxoScope 11 Software for background recording
  • Axon Clampfit 11 Software for data analysis
  • Clampfit Advanced Analysis module (optional) for sophisticated and streamlined analysis

Specifications

Minimum System Requirements Recommended System Requirements
Operating system Windows 7 Pro (32-bit)** Windows 10 Pro (32- or 64-bit)**
CPU PC with 2 GHz processor PC with 2.0 GHz (or faster) Duo Processor
RAM 1.2 GB RAM 4 GB or higher
Display 1440 x 900 display 1920 x 1080 display or higher
Ports 1 USB 1 port (for security key dongle)
1 USB 2.0 port (for Digidata digitizers)
3 USB 2.0 ports
Supported hardware • Digidata 1550B 8-Channel Digitizer
• Digidata 1440A 16-Channel Digitizer
• MiniDigi 1B Two-Channel Digitizer
• Axoclamp 900A Microelectrode Amplifier
• Axopatch 200B Microelectrode Amplifier
• MultiClamp 700B Microelectrode Amplifier
• Most BNC-telegraphed amplifiers also supported*
• Digidata 1550B 8-Channel Digitizer
• Digidata 1440A 16-Channel Digitizer
• MiniDigi 1B Two-Channel Digitizer
• Axoclamp 900A Microelectrode Amplifier
• Axopatch 200B Microelectrode Amplifier
• MultiClamp 700B Microelectrode Amplifier
• Most BNC-telegraphed amplifiers also supported*

Applications

Basic Ion Channel Research Basic ion channel research 
Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell. Learn more.
Cell Pathway Analysis Cell pathway analysis
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc.
Disease Research - Ion channels Disease Research
Ion channels play a role in many diseases including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain, and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease.

hERG Testing - Safety Assessment Safety Assessment
A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow.