Axon™ Digidata® 1550B Low-Noise Data Acquisition System plus HumSilencer

Digidata 1550B

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Overview

Goodbye line-frequency noise. Hello biological signal.

Equipped with up to four HumSilencer™ channels, the Axon™ Digidata® 1550B Low Noise Data Acquisition System enables you to record multiple cells at once for cellular network studies without 50/60 Hz line-frequency noise.

The Digidata 1550B System has three different configurations. Please see the table below. For detailed specifications, please see the datasheet.

Bring a new level of simplicity to your patch-clamp electrophysiology experiments!

While offering the same digitization capabilities as its predecessors, the Axon Digidata 1550B Low Noise Data Acquisition System offers up to four HumSilencer channels. This innovative feature allows scientists to record multiple cells simultaneously for higher throughput or cellular network studies without 50/60 Hz line-frequency noise. With only a single click, eliminate the noise obscuring your biological signals of interest and simplify your workflow.

Last Updated on February 3, 2021

Details

  • Up to four channels that can eliminate 50/60 Hz line-frequency noise and associated high frequency harmonics in less than one second and with a single click
  • Digitizes a wide range of input signals from -10 to +10 V
  • Eliminates a maximum noise amplitude of up to 20 V, peak-to-peak
  • 8 analog input channels to digitize acquired signals up to 500 kHz independently
  • 8 analog output channels to send command voltage output independently
  • 8 digital out channels to control the periphery equipment used in sophisticated experiments
  • Independent analog-to-digital converters for each input channel ensure low crosstalk levels and high data acquisition rates.
  • USB 2.0 connection allows operation on virtually any current PC computer running Microsoft Windows 7 or 10 (32-bit or 64-bit) Operating System, including laptops.
  • 16-bit resolution data
  • State-of-the-art signal-to-noise ratio
  • All signal connectors on the front panel for ease of access and maintenance of the electrophysiology set-up
  • Rack-mount case for tidy installation of all components in the electrophysiology set-up
  • User guide written by scientific consultants, with the assistance of Axon Instruments staff, for straightforward start-up and as an in-depth reference.

 

Last Updated on February 3, 2021

Applications

Basic ion channel research 
Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell.
Cell pathway analysis
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc.
Disease Research
Ion channels play a role in many diseases including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain, and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease.
Safety Assessment
A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow.

Last Updated on February 3, 2021

Specifications

HumSilencer
Maximum input signal
(total of noise + signal)		 ±10 V
Maximum noise amplitude 20 V, peak-to-peak (on a 0 V signal)
Noise cancellation Line-frequency (50 Hz / 60 Hz) and harmonics to 10 kHz
Cancellation response time < 1 second
Analog Inputs
Number of input channels 8 single-ended
Number of ADCs 8
Sampling rates
1 Hz – 500 kHz; Maximum aggregate throughput rate is 500 kHz x 8 input channels = 4 Megasamples/s
Resolution 16-bit
Input range -10.000 V to +10.000 V
Input resistance >1 MΩ
Gain value 1
Analog Outputs
Number of channels 8
Number of DACs 8
Sampling rates 1 Hz –  500 kHz
Resolution 16-bit
Output range -10.000 V to +10.000 V
Output impedance <  0.5 Ω
Output short circuit to signal ground ±25 mA
Digital Outputs
Number of bits 8 (of 16) supported in software
SCOPE Dedicated trigger output
Output driver Advanced CMOS (AC) compatible
Output current ±4 mA source, cable
Type USB 2.0 braided
Length 3 meters
Trigger Inputs
Input type TTL compatible
TAG Rising-edge sensitive
START Rising-edge sensitive

Last Updated on February 3, 2021

Order

Digidata 1550B0 Data Acquisition System, no HumSilencer channel installed
Digidata 1550B1 Data Acquisition System plus one HumSilencer channel
Digidata 1550B4 Data Acquisition System plus four HumSilencer channels

Last Updated on February 3, 2021

Download

DigiData 1550B data sheet:

https://www.moleculardevices.com/sites/default/files/en/assets/data-sheets/dd/cns/axon-digidata-1550b-plus-humsilencer.pdf

Digidata 1550B application note:

https://www.moleculardevices.com/en/assets/app-note/dd/cns/humsilencer-smart-and-simple-feature

Last Updated on February 3, 2021

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