Overview
MEASSuRE is the first and only research tool that combines extracellular electrophysiology with biomechanics and imaging. MEASSuRE integrates three distinct methods into one system: (1) a cytostretcher, (2) a data acquisition system for electrophysiology, and (3) a live cell imaging system. THREE METHODS IN ONE SYSTEM.
MEASSuRE bridges the gap between in vivo and in vitro research by reproducing the mechanical and electrical environment of cells in vivo in a controlled environment in vitro.
Last Updated on June 27, 2022
Details
Capabilities of MEASSuRE
MEASSuRE is a complete solution for researchers to stretch cells/tissue mechanically, image them optically, and record/stimulate electrophysiological activity, separately or concurrently.
Imaging
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before, during and after stretching
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up to 2,000 frames per second at 2MP resolution
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custom, easy-to-use software to independently measure the tissue strain
Electrophysiology
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electrodes stretch with the cells/tissue
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recording/stimulation before, during, and after stretching
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comparison of pre and post stretch electrophysiological activity (normalization)
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soft MEAs on elastomeric silicone substrates
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standard MEAs on rigid substrates availabl
Last Updated on June 27, 2022
DAQ
DATA ACQUISITION CONFIGURATION
Entry-level model solely for electrophysiological measurements on the cells or tissue. Customers who choose this configuration will get access to a high end data acquisition system at low cost. Due to the modular design, they can upgrade to the MEASSuRE configuration by purchasing the additional components. The interface with the cells/tissue are standard rigid MEAs made onglass. Soft MEAs could be beneficial if the substrate stiffness is an factor in cell growth or differentiation. Standard MEAs and soft MEAs can be procured through BMSEED.
CAPABILITIES
- Electrical recording
- Electrical stimulation
- Soft MEAs on eleastomeric silicone substrates
- Standard MEAs on rigid substrates available
- 2×60 channels
- Low cost
Last Updated on June 27, 2022
Stretchable MEA
Traditional MEAs are fabricated using glass or other substrates that are rigid and hard, and therefore do not accurately represent the mechanical environment of cells inside the body. In contrast, stretchable MEAs are fabricated on soft elastomeric substrates, and therefore do more accurately represent the mechanical environment of cells inside the body. In addition, BMSEED’s electrodes are stretchable, enabling research on the effect of mechanical deformation on cellular.
In the table below we compare traditional MEAs with stretchable MEAs.
Traditional MEA
|
Stretchable MEA
|
 |
 |
| Hard substrate (glass) |
Soft substrate (silicone) |
| Rigid (No mechanical motion) |
Elastically stretchable |
| Recording and stimulation |
Recording and stimulation |
| Compatible with BMSEED’s electrophysiology module |
Required for MEASSuRE; compatible with MCS amplifiers |
| Available at BMSEED |
Proprietary; only available at BMSEED |
Last Updated on June 27, 2022
Applications
Cells respond to the mechanical environment they live in.
Cellular Processes Affected By Stretching
- Cell stiffening
- Vascular tone
- Neural signaling
- Cell morphology
- Mechanotransduction
- Angiogenesis
- Ca2+ influx
- Apoptosis
- Proliferation
- Differentiation and
Transdifferentiation
- Inflammation
Last Updated on June 27, 2022
Models
Last Updated on June 27, 2022
How MEASSuRE works
Last Updated on June 27, 2022
Ordering
To order please
Call us at: 631-3936401 or email us at: sales@alascience.com
Last Updated on June 27, 2022
