Description
Rapid focal perfusion is critical for establishing experimental conditions, such as dose response curves. Electronic control of solution exchange is the only way to ensure rapid fluid delivery and reproducibility. By using a VCPlus-4 pressure system with focal outlet, you can configure the system for very basic perfusion requirements or you can optimize the system for the most demanding applications of patch-clamp recording and/or imaging.
VCPlus-4 pressure systems drive fluid by using pressure.
Pressure driven systems can perfuse solution through tubing with very small ID’s. They are ideal for use in focal applications where only a small amount of solution is needed around the preparation. Pressurization also means faster switch rates at the cell membrane. This focal application is especially useful for researchers looking for dose response curves. Pressurized systems include valve manifold with isolation or pinch valves, 5ml pressurized reservoirs, VCPlus controller, power supply, magnetic stand, spill sensor, USB-C cable, and software. Quartz MicroManifold® (QMM) perfusion outlet, BOB-8 TTL breakout box, compression fittings (CF), PR-10 Pressure Regulator, and spill sensor are sold separately.
Key features of the VCPlus-4xP Series include:
- Choice of low-maintenance pinch valves or fast-response isolation
valves
- Customizable reservoir sizes and materials
- DAQ control via analog or TTL input
- Valve control through DAQ, supplied software, or controller
- Optional spill sensor with automatic shutoff to protect microscope
optics
- Quartz MicroManifold® perfusion outlet options for low volume and rapid solution exchange applications
- TTL timestamp to indicate valve opening
- Spike and hold circuit for each valve for rapid valve opening and cool valve operation
Last Updated on March 30, 2026
Details
Each VCPlus-4xP Series system includes the following:
- Magnetic stand with 1 x pole
- Valve manifold with isolation or pinch valves and 5mL pressurized
syringe reservoirs
- VCPlus electronic valve controller with a USB-C cable and software
- DB9-CABLE controller to valve manifold cable
Each VCPlus-4xP Series system features a choice of valves:
- Pinch valves: The 3-way normally open and normally closed pinch
valves require minimal maintenance in long-term perfusion
experiments and have response times of 15-20ms.
- Isolation valves: These 2-way normally closed
isolation valves
are optimized for high-speed solution exchange. These valves are
completely isolated when closed and have response times of 2 to 3ms.
Additional options include:
- Glass reservoirs for volatile solutions
- Spill sensor: used to detect spills around the microscope to prevent damage to expensive optics
- Breakout Box: BOB-8 for TTL trigger inputs
Need to be ordered separately:
- Compression Fittings, CF-1’s, and Quartz MicroManifold ® QMM for fast focal applications
- PR-10 Pressure regulator controller
Last Updated on March 30, 2026
Specifications
Valve Controller:
- Dimensions/Weight: 8″/20.32cm x 6″/15.24cm x 2.5″/6.35cm / 1.5lbs/0.68kg
- Power: 15VDC/3.15A
- Computer Control Input: Analog input 0.5V/valve; TTL high 1 bit/valve; USB 2.0
- Computer Output Monitoring: Analog output 0.5V/valve; Sync TTL high
- Manual Control: Membrane switch 1/valve; mom on/off or toggle on/off
Valve Manifolds:
- Pinch Valves: 12VDC/0.25A each- 3-way normally open or normally closed pinch valves
- Pinch Valve Opening Speed: 15 to 20ms
- Pinch Valve ID Tubing: 0.020″/0.5mm
- Isolation Valves: 12VDC/0.25A each
- Isolation Valve Opening Speed: 2-3ms
- Reservoirs : 5mL pressurized syringes with 3-way stop cock luer valves
Sample pressurized flow rate: 1mL in 9 minutes @ 10 PSI / 70kPa through QMM with 100μm ID tubes
Last Updated on March 30, 2026
Accessories
Last Updated on March 30, 2026
Ordering
| PART# |
DESCRIPTION |
| ALA VCPlus-4PP |
8 Channel Pressurized Perfusion System: pinch valves, magnetic stand with pole, valve manifold, 5mL pressurized reservoirs, VCPlus-8C controller and power supply, cable, and software. 8 x CF-1’s and QMM-4WT or MLF-8 and tubing not included and MUST be ordered separately. |
| ALA VCPlus-4CLP |
4 Channel Pressurized Perfusion System: isolation valves, magnetic stand with pole, valve manifold, 5mL pressurized reservoirs, VCPlus-4C valve controller and power supply, cable, and software. 4 x CF-1’s and QMM-4WT or MLF-4 and tubing not included and MUST be ordered separately. |
| ALA VCPLus-4C |
4 channel VCPlus electronic valve controller including power supply, cables and software |
| ALA VC3-PS |
VCplus electronic valve controller power supply |
| ALA QMM-4 |
Quartz MicroManifold® 4 to 1 channel perfusion outlet manifold with 100um or 200um ID (please specify) tubing and tip (other sizes available – please call or email to inquire) |
| ALA QMM-4WT |
Quartz MicroManifold® 4 to 1 perfusion outlet manifold with 100um or 200um ID (please specify) tubing and tip (other sizes available – please call or email to inquire) and clear teflon tubing installed |
| ALA MLF-4 |
MilliManifoldTM 4 to 1 channel perfusion outlet manifold made of 500um ID polyimide tubing with 1/16″ barb fittings |
| ALA 60mlRES |
60mL pressurized reservoir assembly with 3-way luer valve |
| ALA 10mlRES |
10mL pressurized reservoir assembly with 3-way luer valve |
| ALA 5mlRES |
5mL pressurized reservoir assembly with 3-way luer valve |
| ALA PV |
Replacement pinch valve |
| ALA CL |
Replacement isolation valve |
| ALA DB9-CABLE |
Replacement VCPlus controller to valve manifold cable |
| ALA BOB-8 |
BNC breakout box for TTL trigger inputs |
| ALA VM-STAND |
Replacement valve manifold stand: magnetic base and 2 rods |
| ALA VC38AIRMAN |
Replacement pressurized air manifold tubing set |
| ALA SPILSNSR |
Replacement Lasso Spill Sensor with connector |
| ALA FEP-1 |
4m clear Teflon tubing with 230um ID and 600um OD (for 100um ID QMM’s) |
| ALA FEP-2 |
4m clear Teflon tubing with 380um ID and 760um OD (for 200um ID QMM’s) |
| ALA CF-1/2 |
Compression fitting for PE-10/20/FEP-1/2 tubing to 1/16″ ID tubing |
| ALA TUBING-2 |
10′ 1/16″ ID and 1/8″ OD PVC tubing |
| ALA TUBING-4 |
2′ silicone pinch valve tubing for pressurized flow |
Last Updated on March 30, 2026
